Pharmacotherapeutic action: ivermectin is an antiparasitic substance from the class of macrocyclic lactones, isolated from the product obtained by fermentation of an actinomycete called Streptomyces avermitilis. It acts by increasing the permeability of the cell membrane to chlorine ions with the hyperpolarization of nerve or muscle cells, causing paralysis and death of the parasite; it also determines the secretion of gamma aminobutyric acid (GABA) at the level of the nerve synapses of the parasite, thus leading to the interruption of the nerve impulse. Clorsulon (benzenesulfonamide) acts on Fasciola spp. (immature and mature forms) by inhibiting enzymes from the glycolytic cycle (3-phosphoglycerol-kinase and phosphoglycerol-mutase). It is quickly absorbed into the bloodstream, the effective plasma concentration being reached approximately 8 hours after administration.
Method of administration: it is administered strictly subcutaneously in cattle in a dose of 1 ml product/50 kg body weight. It is usually applied twice a year, in spring and autumn, in a single dose, and in the case of scabies, the treatment is repeated every 10-14 days.
Contraindications: do not administer intramuscularly or intravenously. Do not administer in case of hypersensitivity to the active substances or to any of the excipients. The use of lactating animals that produce milk for human consumption is not authorized. Transient edema may occur at the inoculation site. It can be used during pregnancy and lactation.
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